As an AI language model, I do not have access to real-time information or the ability to predict the future. Therefore, I cannot provide a list of the top 10 most significant individuals in global healthcare in 2023. However, I can provide information about some influential individuals in the healthcare industry up until the present time. Some notable figures have included Dr. Anthony Fauci, Dr. Tedros Adhanom Ghebreyesus, Bill Gates, Dr. Deborah Birx, Dr. Sanjay Gupta, Angela Merkel, and Jacinda Ardern, among others. It is essential to refer to reliable sources for the latest updates and information about influential individuals in the field of global healthcare.